Wouldn’t it be cool if you could use a magnet to pull cancer cells away from normal tissue? But, you say, there aren’t tiny magnets in cancer cells. And besides, even if there were little magnetized cells, how could you tear them apart from a solid tumor?
You’d be correct on both counts, but not as imaginative as a research team from the Georgia Institute of Technology . To solve the first problem, Scarberry et al. took cobalt/iron (i.e., magnetic) nanoparticles and hooked them to a peptide that targets the surface of ovarian cancer cells ( Journal of American Chemical Society Web release : 9 July 2008).
When given to mice, the particles are taken up by free-floating cancer cells in the peritoneal (stomach) cavity. Apply a magnetic field and, voila, the nasty tumor cells head straight toward the magnet. Although not useful against a primary tumor mass, this might prove valuable in removing metastatic or residual cancer, both of which ca...
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Forget What You Learned in High School ChemistryFrom: periodictabloid.chemheritage.org
Post Date: 2008-01-10 04:50:41
Anyone who remembers much chemistry knows that sodium chloride is common table salt. Magnesium chloride may present a bigger memory challenge since it has no such common single use, but it is an important source for magnesium metal (think mag wheels) and is also used in the production of tofu from soy milk. Practicing chemists will have no trouble recalling the formulas—NaCl and MgCl2—but civilians may have to dig deeper into memory to get these chemical representations.
Whoever y...
more The Great Debate?From: periodictabloid.chemheritage.org
Post Date: 2008-01-07 04:00:29
Perhaps you are weary of the interminable debates among those seeking to be the next POTUS (President of the United States). Don’t worry; it’s not antidemocratic to feel so, especially since the actual election is nearly a year off. Also, the contenders and the questions have probably blended toward a dull blandness, whatever your personal viewpoint or favorite candidate.
And do any of them ever talk about science? Not so far, at least in any serious and informed way. But, in cas...
more Magic BulletsFrom: periodictabloid.chemheritage.org
Post Date: 2008-01-04 04:42:49
The holy grail of medicinal chemistry is the so-called magic bullet. This is a brilliant substance that seeks out a single molecular target in the body. It then binds to the target, brings about its intended effect, and leaves no accidental toxic repercussions. There is no such thing, of course, although penicillin G may come closest of all common pharmacological agents.
Currently, when an active drug candidate is in hand, it undergoes a huge battery of cellular and animal tests to determine ...
more A New Kid on the BlockFrom: periodictabloid.chemheritage.org
Post Date: 2008-01-02 05:35:15
The blogosphere is vast, largely untamed, and does not enjoy a high signal-to-noise ratio. So why start yet another one? Pride, envy, greed, or any of the other seven deadly sins would not seem to be a good reason. Perhaps the only motive that makes sense is if you have a unique vantage point from which to attempt something original.
So, a leap of faith. I will assume that a lengthy background in basic scientific research (my focus was on cancer chemotherapy) and more years than I can...
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